Semantic closure is the physical state of the system that enables it to begin functioning and to persist over time. It rests on the observed reality that, in order to function, the system must successfully specify itself as well as specify how to successfully interpret its specification. In short, semantic closure requires the simultaneous coordination (relation) between a) the physical state of the sequences that specify the constituents of the process, with b) the physical state of the sequences that specify the interpretive constraints, and c) inexorable law — i.e. that whatever products result from those iterations of sequences must have the physical properties required to cause them to read the sequences, produce the products, make a copy of the descriptions, and provide it to the next generation along with a set of its interpretive constraints. If this coherence does not exist, the system cannot begin to function and cannot persist over time. The nature of issue should be evident.